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KMID : 0616120180490030219
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Korean Journal of Pharmacognosy
2018 Volume.49 No. 3 p.219 ~ p.224
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Five Di-caffeoylquinic Acid Derivatives and a Coumarin from the Hot-water Extract of Artemisia annua
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Rho Tae-Woong
Park Chan-Young
Kim Seon-Hee
Yoon Kee-Dong
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Abstract
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Artemisia annua L. (Compositae) is an annual herb, which has been traditionally used as an antipyretic and hemostatic agent with the herbal medicine name of Cheong Ho (菁蒿) in Korea and China. In this study, five di-caffeoylquinic acid derivatives and a coumarin were determined from the hot-water extract of aerial parts of A. annua. The structures of isolates were elucidated to be 1,3-di-O-caffeoylqunic acid (1), 3,4-di-O-caffeoylquinic acid (2), 3,5-di-O-caffeoylqiunic acid (3), 1,5-di-O-caffeoylquinic acid (4) and 4,5-di-O-caffeoylquinic acid (5) and scopoletin (6). The presence of 1,5-di-O-caffeoylquinic acid (4) is firstly reported from A. annua in the current study.
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KEYWORD
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Artemisia annua, Hot-water extract, Di-caffeoylquinic acid, Coumarin
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